Le'garde as the PC doesn't really unlock anything different in regards to endings, or much of any other interactions besides being able to rape the Girl and I think Ragnvaldr attacked me on-sight when I found him in the backyard. I've been going through the S-endings, only cheating a little after I've done at least one decent run, then cheating a lot if I still fail.
>At least make decent headway in a pure run with no cheats, no phase walk, and no empty scroll generated new god souls
<Die
>At least make decent headway in a pure-ish run with no phase walk and no empty scroll generated new god souls, but start with 99 lucky coins so RNG is more in my favor
<Die
>Cheat the hell out of it as fast as possible
I ended up totally cheating with Cahara and D'arce. For Cahara, I hit a bear trap and lost both my legs right after picking up the old passage key, so I had to crawl all the way to the crown, and then crawl all the way out of the dungeon. Apparently phase step doesn't work if you have no legs to step with. For D'arce, I was having a really good run, then I got softlocked by a bug right in front of Le'garde's prison when I already had the Cube of the Depths. Surprisingly, I beat Enki's S-ending in a pure run with no cheats, even though it's the second hardest of the basic S-endings. Next is Ragnvaldr, then the Girl, but I doubt I'll beat Ragnvaldr in a pure run.